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The majority of the study carried out on cannabinoids and pain has included the whole plant, with both non-psychoactive cannabidiol (CBD) and psychoactive tetrahydrocannabinol (THC) being used.
A study reported in Neurotherapeutics confirmed that CBD Dosage treatment was therapeutic for patients with general and neuropathic pain usually by interacting with alpha-3 glycine receptors (which involves the process of sensing pain) to reduce pain and inflammation.
Research into the effectiveness of a CBD dosage used as a single treatment for pain is still in progress. CBD is found in several studies to regulate pain. However, it is found that the interaction of THC, a type of cannabinoid with cannabidiol (CBD) is found to be a promising catalyst in reducing pain.
It has been found that cannabinoids such as CBD may also effectuate its properties indirectly by working on a G-protein coupled receptor known as TRPV-1, or the vanilloid receptor (which is known as a molecular pathway for pain and various underlying diseases). Cannabinoids are found to activate this vanilloid receptor is activated by means of supporting anandamide, (an endocannabinoid that acts to regulate pain), with CBD known to repress the FAAH enzyme (which breaks down cannabinoids) in a bid to support anandamide to regulate the pain, this may be the mechanism of action CBD used to reduce pain. Essentially, CBD binds to the pain receptors and is found to mediate the sensation of pain throughout the body which providing the therapeutic benefit of acting as an anti-inflammatory
Further Reading: Cannabinoids in the Management of Pain
Being that CBD supports the Anandamide, it is good to note that Anandamide is a notable endocannabinoid that is effective in reducing pain. It is a lipid-based neurotransmitter that has been compared to THC. It is known that some individuals suffer from Clinical endocannabinoid deficiency, a condition which limits the production of anandamide in the right amounts needed to guarantee optimum state in the endocannabinoid system. CBD helps with this deficiency by supporting the natural production of Anandamide.
In addition, CBD have been proven to minimize the effects of conditions caused by pain, for example, inflammation. Cannabinoids have a surprisingly notable effect on the body’s immune system because of its ability to interact with CB2 receptors, which has an association with the immune system. Keeping the endocannabinoid system managed with consistent prescribed CBD dosing may help diminish the possibility of Regular / Chronic / and neuropathic pain.
There are a couple of approaches to managing pain with the use of CBD products. Whether with neuropathic pain that often occurs very rapidly and involves intense, or chronic pain – that may not be as involving as neuropathic pain, patients are suggested to use an admission technique that enables quick delivery of CBD into the bloodstream and the endocannabinoid system.
Cannabidiol is lipid soluble which means absorption into the body is rapid, which is advantageous when it comes to producing a faster onset relief. Although some CBD products such as CBD edibles have slow absorption (Depending on the dosage), however, the effects are felt for a longer period of time. Sublingual CBD as well as vape-able CBD is found to absorb quicker than edibles.
While there is still a considerable amount of investigations to be carried out by researchers on the field of CBD dosing for pain, Cannabinoids and its uses in neuropathic pain, the signs are exceptionally reassuring.
What’s more, individuals need to understand that CBD is a safe substance for the treatment of various ailments. Although, in reality, modern medicine is yet to officially carry out continuous research on cannabinoids and dosage, the many testimonies about its therapeutic effects are from individuals who were looking for alternative options from perhaps risky pain medication.